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Thoroughly revised and updated, this Fourth Edition is the only current book that integrates cellular and subcellular elements of cardiovascular physiology in the analysis of physiologic and pathophysiologic responses. In straightforward terms, with more than 600 diagrams and illustrations, the book explains the key principles crucial to understanding how the cardiovascular system and its components function and malfunction.

For this edition, Dr. Opie has enlisted eight internationally eminent co-authors and added a new chapter on cell signaling. The chapters on physiology of the ECG and arrhythmias contain many more ECGs. More than half of the illustrations—including 12 color plates—are new.

• Sales Rank: #1477276 in Books
• Published on: 2003-12-01
• Original language: English
• Number of items: 1
• Dimensions: 1.42" h x 6.36" w x 9.66" l,
• Binding: Hardcover
• 640 pages

From The New England Journal of Medicine
Cardiovascular disease is still the chief cause of death in our society. It is therefore not surprising that the field of cardiovascular science continues to expand rapidly, particularly at the cellular and subcellular levels. This expansion can cause difficulties for clinicians and medical students. Yet an understanding of the "new" physiology is essential for the proper use of new forms of medical technology and pharmacologic agents. It is in this context that Lionel Opie's opus expertly integrates cellular and subcellular elements of cardiovascular physiology in an analysis of physiologic responses.

The book starts with an overview of the cardiovascular system, including descriptions of electrophysiologic principles, excitation-contraction coupling, and mechanisms of receptor and signal transduction. The discussion of these mechanisms then leads to a review of cardiac function and finally, to an integrative analysis of the circulation and pathologic conditions that affect it. A particularly strong feature of this book is that the discussion always goes back to cellular and subcellular mechanisms, maintaining the connection between cellular physiology and overall integrative physiology.

An omission from this otherwise comprehensive book is a discussion of molecular mechanisms. There is nothing on transcriptional and translational regulation of enzyme systems and receptors, nor is there much information about new experimental models, including transgenic animals. Perhaps the next edition will rectify this oversight.

This book is well written. Each chapter has numerous figures, a large proportion of which were prepared especially for this new edition. There are also many summary tables. A minor criticism is that the abundant figures, some of which are redundant, can cause confusion by illustrating the same point in different ways.

Dr. Opie has given this book a very nice scholarly touch by placing a quote at the beginning of some chapters and by including historical notes throughout the text. Each extensively referenced chapter allows the reader to look up the primary sources and learn about any of the subjects in more detail.

The book has been designed to work as a textbook. Each chapter ends with a summary of the major points and sets of questions for students and cardiologists in training. This makes the book ideal not only for students and trainees but also for cardiologists who want to review cardiovascular physiology and the principles underlying new therapeutic agents.

How does this book relate to the book by Arnold Katz with a similar name, Physiology of the Heart (Second edition. New York: Raven Press, 1992)? Opie deals with this in his preface. He says that his book should be viewed as a companion to and not a competitor of Katz's book and other cardiology textbooks. I completely agree. Opie's book provides information on pharmacology and integrative physiology that complements information on mechanisms related to contraction and energetics discussed in Katz's book. But other cardiovascular textbooks contain more clinical and therapeutic information.

The one fault I find with this book is the lack of appreciation of the integration of the heart with the venous circuit and of the effect of this integration on cardiac function. For example, in the section on cardiac output and exercise, the author states, "During dynamic exercise, it is the increased heart rate that provides most of the adaptation. In addition, there is an increased venous return, which acts by the Frank-Starling mechanism." Since cardiac output must equal venous return in the steady state, any increase in cardiac output must equal the increase in venous return. There is no additional increase in venous return. The failure to recognize this point leads to a number of weaknesses in the integrative sections and sometimes to a failure to appreciate which cardiac variables are independent and which are dependent. However, this point does not detract from the overall usefulness of this very fine book.

Reviewed by Sheldon Magder, M.D.
Copyright © 1998 Massachusetts Medical Society. All rights reserved. The New England Journal of Medicine is a registered trademark of the MMS.

Review
Circulation, 21-SEP-04, Volume 110, Issue 12, William H. Barry, MD, University of Utah Health Sciences Center, Salt Lake City, UT -- "Many excellent basic cardiovascular science and clinical cardiology texts are available to help the academic or practicing cardiologist keep abreast of the rapid developments in these areas. Few, however, combine a lucid and up-to-date description of new and established findings in laboratory research with an informed discussion of their clinical relevance to the pathophysiology and treatment of cardiac disease. This new edition of Dr. Opie's highly regarded book does this extremely well..." "I believe this book should be required reading for 1st-year cardiology fellows and will be very useful as well to the established cardiologist wishing to maintain a current knowledge base in cardiovascular science that is relevant to their practice."-Circulation

Most helpful customer reviews

6 of 6 people found the following review helpful.
Heart Physiology
By Mark D. Kittleson
We just completed using this text in a study group setting. I have about 25 years of cardiovascular pathophysiology background but had never read through this book in detail so I looked forward to reading it. Unfortunately, I was very disappointed. Physiology, especially cardiovascular physiology, is a logical discipline. Heart Physiology, however, is not written in a logical fashion in many places, especially in the organ physiology and pathophysiology sections. In fact, in places the presentation borders on being incoherent. Material is repeated and sometimes this information is contradictory. Some material in the pathophysiology sections is just plain wrong and in others is misleading. Needless to say I am currently searching for a replacement for next year's group.

6 of 6 people found the following review helpful.
Perfect for the young cardiac physiologist
By A Customer
This book is perfect for the young cardiac physiologist. My interests are concentrated on the metabolism of the heart and while the Author has spent many years of research on glucose metabolism this book gives an excellent broad based understanding on heart physiology. It is considered the "bible" in the lab I work in. Well recommended to undergraduate as well as postgraduate students looking for clear explanations on different concepts and theories regarding the heart.

0 of 0 people found the following review helpful.
Great Book
By Harry
If you want to know more about the heart that you have then buy this book.
It is well worth the price that is being asked of it.

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León es un joven profesor de literatura en el Liceum Copernicus de Varsovia. Destrozado por su ruptura sentimental, el As de corazones compagina su trabajo con su sueño de convertirse en escritor. Mientras se divierte con otras mujeres en busca de la felicidad sin éxito, su corazón se quedará atrapado cuando, en el inicio de curso, conozca por fin a su nueva alumna: Zofia Komarnicki. Varias copas, templanza. Una propuesta indecente. El romance prohibido entre el profesor y la adolescente, no sólo los llevará a una situación social comprometida. La joven, no será una chica normal de ojos azules. El desliz amoroso entre amantes, producto de una fantasía, destapará una caja de truenos que convertirá el mañana de León en otro mundo que no entraba en sus planes. "Quién iba a pensar que una joven traería tantos problemas." "Amor postmoderno, señales marcadas, conversaciones cortadas y crónica ácida de un treintañero en el extranjero que juega con la despreocupación y el sinfuturo." Pablo Poveda es autor de otras novelas como Motel Malibu, Sangre de Pepperoni, Ella Es Punk Rock o Héroes Modernos. Tras dos años de pausa, vuelve con esta obra, un thriller con forma de romance que acaba entre acción al puro estilo de autores como Camilla Lackberg, Paula Hawkins, Blake Crouch, Ellen Marie Wiseman o Michael Hollow. "Aparentemente una fantasía de la que muchos hemos sido expectadores y que se convierte en un thriller psicológico entre hombres, orgullo y el propio ego del protagonista." "Hombres buenos, malos, una historia de suspense romántica sin descuidar la acción." "La capital de Polonia es el escenario de un anti-héroe que sin quererlo, se ve amenazado por políticos y revolucionarios en tierra de nadie." "La adolescencia puede ser el rincón más sucio del alma."

• Sales Rank: #1924182 in Books
• Published on: 2015-07-17
• Original language: Spanish
• Number of items: 1
• Dimensions: 8.00" h x .36" w x 5.00" l, .36 pounds
• Binding: Paperback
• 158 pages

Most helpful customer reviews

1 of 1 people found the following review helpful.
La primera mitad del libro tiene su gracia y atrapa ...
By Cliente de Amazon
La primera mitad del libro tiene su gracia y atrapa, pero posteriormente como que la historia no amarra y es poco verosímil. Aparte de esto, la edición para Kindle, que fue la que leí, tiene muchos errores de edición como puntuación en lugares equivocados y párrafos duplicados que entorpecen la lectura. El trabajo de edición haría la lectura cómoda, mas me temo que no podría recomendar el texto.

1 of 1 people found the following review helpful.
Se mueve entre convencionalismos y tramas de telenovelas con un ...
By Stella Contreras
Se mueve entre convencionalismos y tramas de telenovelas con un tinte de suspenso, aunque no lo es totalmente. La narración no aporta riqueza literaria, sólo cuenta lo que pasa, parece un argumento cinematográfico. Incluso usa una palabra de manera incorrecta, no voy a decir cual. Dudo que el narrador sea español, como pusieron en un comentario.

1 of 1 people found the following review helpful.
Cuidado con las menores
By Jose M Celano
es una historia muy particular respecto de un profesor español dando clases en un escuela en Polonia.el libro se lee facilmente pero me dejo sabor a poco una vez finalizado. es una novela desconcertante y un final poco creible.

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• Sales Rank: #8157802 in Books
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• Published on: 1977-12
• Original language: English
• Number of items: 1
• Binding: Hardcover
• 656 pages

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[E430.Ebook] Download Ebook Practice Makes Perfect German Sentence Builder (Practice Makes Perfect Series), by Ed Swick

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Practice Makes Perfect German Sentence Builder (Practice Makes Perfect Series), by Ed Swick

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Practice Makes Perfect helps you put your German vocabulary and grammar skills together!

You may have all the vocabulary down pat and every grammar point nailed--but without the skill of knowing how to put these elements together, communicating in your second language would be nearly impossible. Practice Makes Perfect: German Sentence Builders picks up from where other grammar books leave off, showing you the variety of structures and how to combine them to make solid sentences. And like every Practice Makes Perfect title, these books feature crystal-clear explanations, numerous realistic examples, and dozens of opportunities to practice, practice, practice!

• Sales Rank: #325092 in Books
• Published on: 2009-07-22
• Released on: 2009-07-22
• Original language: English
• Number of items: 1
• Dimensions: 10.60" h x .40" w x 8.90" l, .85 pounds
• Binding: Paperback
• 192 pages

About the Author

Ed Swick taught German for thirty years. He is the author of Practice Makes Perfect: German Pronouns and Prepositions and Practice Makes Perfect: German Vocabulary.

Most helpful customer reviews

57 of 57 people found the following review helpful.
Comprehensive verb review
By BrianD
This is a very comprehensive German verb workbook and I found it to be exactly what I needed to prepare for an upcoming trip to Germany and Austria. This product is probably best for a student with some familiarity with the language, as it is very comprehensive. I have had two years of High School German and one year of college level German, albeit many years ago, and found this book to be an ideal review. With Germanic languages, the verb is integral to the listener's ability to understand the meaning of a given sentence, and this guide enables the student to attain the level of confidence required to understand the action. I wish I had used this product when I was in high school, as it would have certainly accelerated my progress with the language. I have also tried Rosetta Stone and other similar DVD-based products, and found them to be too slow for the type of review I needed. As a break to my German verb studies, I found German news programs via the web to be an ideal supplement to this guide, allowing me to tune my ear to normal conversational German. In summary, I find this product very useful and give it an A-plus. Sehr gut!

32 of 33 people found the following review helpful.
Disappointing
By George Lang
I write "disappointing" as a life long language teacher and learner. My main criticisms are two. First, the production values are low, with examples apparently pasted into the explanations in what looks like photocopies (hence these phrases are "dead" in a digital reader, cannot be searched for or marked up).

My second problem is bad editing. There are a huge number of capitalization errors, which are crucial to correct German. These add to the impression that the book has somehow been cut and pasted by non-native speakers, native-speakers never having tolerated such inaccuracies. As an intermediate student of German, it is not for me to say that the sentences are unidiomatic, but compared to texts and exercises prepared in German (such as Dreyer and Schmitt's Lehr- und überungsbuch der deutschen Grammatik -- alas, not in ebook form), the sentences often ring false or at least awkward. Save your money and if you have to, go back to paper books.

14 of 15 people found the following review helpful.
Good resource, ridiculous amount of typos
By April S.
While the lessons are explained well and the exercises are helpful, the number of typos is completely distracting. There is nearly a noun capitalization typo in every exercise. This isn't just an occasional, hard-to-find mistake, so I don't understand how this wasn't spotted before publication. Very unprofessional.

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In this book (previously published as Crippled America), we’re going to look at the state of the world right now. It’s a terrible mess, and that’s putting it mildly. There has never been a more dangerous time. The politicians and special interests in Washington, DC are directly responsible for the mess we are in. So why should we continue listening to them?

It’s time to bring America back to its rightful owners—the American people.

I’m not going to play the same game politicians have been playing for decades—all talk, no action, while special interests and lobbyists dictate our laws. I am shaking up the establishment on both sides of the political aisle because I can’t be bought. I want to bring America back, to make it great and prosperous again, and to be sure we are respected by our allies and feared by our adversaries.

It’s time for action. Americans are fed up with politics as usual. And they should be! In this book, I outline my vision to make America great again, including: how to fix our failing economy; how to reform health care so it is more efficient, cost-effective, and doesn’t alienate both doctors and patients; how to rebuild our military and start winning wars—instead of watching our enemies take over—while keeping our promises to our great veterans; how to ensure that our education system offers the resources that allow our students to compete internationally, so tomorrow’s jobseekers have the tools they need to succeed; and how to immediately bring jobs back to America by closing our doors to illegal immigrants, and pressuring businesses to produce their goods at home.

This book is my blueprint for how to Make America Great Again. It’s not hard. We just need someone with the courage to say what needs to be said. We won’t find that in Washington, DC.

• Sales Rank: #850 in Books
• Published on: 2016-07-12
• Released on: 2016-07-12
• Original language: English
• Number of items: 1
• Dimensions: 8.37" h x .60" w x 5.50" l, .0 pounds
• Binding: Paperback
• 208 pages

About the Author
Donald J. Trump is the very definition of the American success story, continually setting the standards of excellence while expanding his interests in real estate, sports, and entertainment. He is a graduate of the Wharton School of Finance. An accomplished author, Mr. Trump has authored over fifteen bestsellers and his first book, The Art of the Deal, is considered a business classic and one of the most successful business books of all time. Mr. Trump has over eight million followers on social media and is a frequent guest across a variety of media platforms.

Excerpt. © Reprinted by permission. All rights reserved.
Crippled America PREFACE YOU GOTTA BELIEVE
PEOPLE SAY THAT I have self-confidence. Who knows?

When I began speaking out, I was a realist.

I knew the relentless and incompetent naysayers of the status quo would anxiously line up against me, and they have:

The politicians who talk a great game in campaigns—and play like total losers when they try to actually govern because they can’t govern; they don’t know how to govern.

The lobbyists and special interests with their hands in our pockets on behalf of their clients or others.

The members of the media who are so far lost when it comes to being fair that they have no concept of the difference between “fact” and “opinion.”

The illegal immigrants who have taken jobs that should go to people here legally, while over 20 percent of Americans are currently unemployed or underemployed. Believe me, they’re all over the place. I see them. I talk to them. I hug them. I hold them. They are all over the place.

Congress, which has been deadlocked for years and virtually unable to deal with any of our most pressing domestic problems, or even the most basic ones, such as passing a ­budget. Think of it: a little thing like passing the budget. They don’t even have a clue.

Meanwhile, the bedrock of this country—the middle class—and those 45 million Americans stuck in poverty have seen their incomes decline over the past 20 years. Understandably, their disenchantment and frustration at what’s happening grows every day, and it gets worse and worse and worse.

And even our lawyers and judges, the reflective “wise men,” have been stepping all over the US Constitution, the bulwark of our democracy. They have recklessly appointed themselves to be policy makers, because our actual elected officials are paralyzed by partisanship. They can’t move; they can’t act. They are totally impotent.

As for the presidency and the executive branch, the incompetence is beyond belief.

As I write this, Russian president Vladimir Putin is totally outmaneuvering our president by putting together a coalition in Syria that will make Putin the only effective leader in the world. He and his allies—most notably Iran—have positioned themselves exactly where President Obama and our military have failed miserably for years. They are total failures. They are not leaders. We are no longer a leader. Putin has become the leader, and it’s an embarassment to our country.

We’ve wasted literally trillions of dollars in the Middle East, with virtually nothing to show for it except for alienating our best ally, Israel. To make matters worse, we’ve negotiated a worthless and costly nuclear treaty with Iran (now Russia’s best friend) on the supposition that it will lead to greater harmony and world peace, which it won’t. It will lead to just the opposite.

The idea of American Greatness, of our country as the leader of the free and unfree world, has vanished.

Despite all of these challenges—and actually because of the challenges—I decided to do something about it. I couldn’t stand to see what was happening to our great country. This mess calls for leadership in the worst way. It needs someone with common sense and business acumen, someone who can truly lead America back to what has made us great in the past.

We need someone with a proven track record in business who understands greatness, someone who can rally us to the standard of excellence we once epitomized and explain what needs to be done.

When I started speaking out, I had no idea what the reaction would be. I know I’m a great builder, I’ve built buildings all over the world. I’ve had tremendous success. But I hadn’t fully exposed my political thoughts and ideas to restore America’s greatness.

I also knew that the Trump brand is one of the world’s great icons of quality and excellence. Everybody talks about it. Everybody knows about it. It’s very very special. I’m very proud of it. Our buildings and resorts now stand very proudly (and beautifully) all over the United States and in many other countries.

I started with the issue of illegal immigration, and proposed building a major wall that would be very high and completely impervious to the flood of immigrants who we don’t want or need here illegally. We love people coming in, but not when it’s done illegally.

Suddenly, Americans started to wake up to what was going on with regard to illegal immigration. Despite the large number of candidates who were running for the Republican nomination, what I was saying started to really hit home with people, and ­everybody picked it up and they picked it up gladly.

I started drawing crowds so large that we had to move our rallies into football stadiums and convention centers. The first national debate drew 24 million viewers, which set a record for cable television. Despite some of the ridiculous, antagonistic questions—or maybe because of them—I fought back as I always do and began to explain my vision. As a result, most people thought I won the debate.

People were applauding. All of a sudden, people who had never cared about elections or never voted were rushing to our rallies. The rallies became massive. The crowds were unbelievable. The enthusiasm was based on pure love and love of what we were doing.

The media, the politicians, and the so-called leaders of our country reacted in horror. But I persevered and went directly to the people, because I don’t need anyone’s financial support, nor do I need anyone’s approval of what I say or do. I just had to do the right thing. I had to do it. I had no choice. I see what’s happening to our country; it’s going to hell. I had to do it.

I have now begun to fill in some of the details of my vision. I’ve released a tax plan that gives the middle class and those with lower incomes a chance to keep more of what they earn, while restructuring how the richest Americans will be paying taxes.

I’ve committed to a truly more powerful military, one prepared and equipped to stand up to any and all of our foes. When we draw a line in the sand, it needs to mean something to all—­especially our enemies.

I’ve introduced a whole new approach to job creation by encouraging companies to bring more of their jobs and manufacturing back to America (home where it belongs), along with the trillions of dollars currently being held in foreign banks overseas. We’re bringing that money back. It’s a massive amount of money. And guess what? Lots of good things are going to happen. They’re going to spend that money on roads, on bridges, on companies, on jobs. It’s going to be amazing.

I’ve explained why Obamacare is a costly, ludicrous solution to our health care woes and one which must be repealed and replaced with a much better option. We need to fix the problem by creating competition in the private sector between insurance companies, and by allowing patients to choose the family doctors they want. This will be a much better plan, a much less costly plan—better doctors, better service. It will be something really special. And think of it: the United States will save a fortune as a country. People will be better served. A combination that cannot be beat.

Competition is a magic word in education as well. Parents should have the right to choose the schools where their kids can get the best education. The weaker schools will be closed, and ineffective teachers will be fired. One-size-fits-all ­education—Common Core—is bad. It’s not going to happen. We don’t want our children to be educated from Washington. We want local education. Education should be ­locally based.

Domestically, we need to undertake a massive rebuilding of our infrastructure. Too many bridges have become dangerous, our roads are decaying and full of potholes, while traffic jams are costing millions in lost income for drivers who have jobs in congested cities. Public transit is overcrowded and unreliable and our airports must be rebuilt. You go to countries like China and many others and you look at their train systems and their public transport. It’s so much better. We’re like a third-world country.

I could go on and on regarding many of the ideas I’ve written about in this book, and more that will be forthcoming. But let me add that while my critics are pushing their policy agendas, the last thing we need are more plans that evaporate after the elections.

What we need is leadership that can deal with our mess and begin to apply practical solutions to our problems. My goal is not to design hundreds of pages of government regulation and red tape like others propose. We need to outline ­commonsense policies and then knock some heads together if necessary to make them work. The fact is we are over-regulated. People can’t move. They’re stymied. Companies can’t be built. We’re over-regulated.

I know how to deal with complex issues and how to bring together all the various elements necessary for success. I’ve done it for years and have built a great company and a massive net worth.

This book is designed to give the reader a better understanding of me and my ideas for our future. I’m a really nice guy, believe me, I pride myself on being a nice guy but I’m also passionate and determined to make our country great again.

It’s time we turn America around from despair and anger to joy and accomplishment. It can happen, and it will happen.

Our best days still lie ahead. There is so much untapped greatness in our country. We’re rich in natural resources, and we’re rich in human talent.

Enjoy this book—and together, let’s make America great again!

Most helpful customer reviews

6 of 6 people found the following review helpful.
Five Stars
By Ben Wilmot
Trump is as arrogant in print as on TV

2 of 2 people found the following review helpful.
Its the US regime that is crippled, not the ideal or even the masses...not by a long shot...yet.
By C.R. Knight
Makes plenty of sense...now if only he can get in there and do it! He needs to be more optimistic and say "Help is on the Way!"

2 of 2 people found the following review helpful.
Four Stars
By jward
If you read his early books you will see a consistent theme. Qualiy, quality, quality.

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